The Africa Centres for Disease Control and Prevention, Africa CDC, is in discussion with Bavarian Nordic on the transfer of technology to enable African manufacturers of Mpox vaccines.
Dr Jean Kaseya, Director-General of Africa CDC, announced this during the weekly Mpox media briefing on Tuesday.
The News Agency of Nigeria, NAN, reports that Bavarian Nordic is the sole global producer of the Mpox vaccine.
Africa in talks with Bavarian Nordic on technology transfer but What is this Mpox Vaccine – Rokmer Pharma
Kaseya expressed gratitude to the company for agreeing to the technology transfer, which would allow Africa to manufacture its vaccines.
He explained that Africa CDC aimed to have 10 million doses available by the end of 2025, adding that Bavarian Nordic had assured the organisation that the target was achievable.
He, however, said that while this represents a longer-term solution to the Mpox outbreak affecting 12 African countries, more immediate measures are needed.
He highlighted the need for donations from wealthier countries to address the crisis in the short term, referring to this as an “emergency humanitarian era.”
He also commended the European Union, EU, for procuring 215,000 vaccine doses for the continent.
“In the past week alone, Africa has seen an increase of 1,405 Mpox cases, bringing the official total to 18,910.
“The biggest increase was in the Democratic Republic of Congo, the epicentre of the outbreak, which now has 17,794 cases, an increase of 1,030.
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“However, armed conflict in eastern DRC is hampering efforts to curb the outbreak,” he said.
According to him, surveillance remains suboptimal in some countries.
“Other countries, including Burundi, the Central African Republic, and Nigeria, have also seen an uptick in cases.
“Burundi’s cases jumped from 265 to 572, while the Central African Republic’s cases increased from 206 to 263, and Nigeria’s from 24 to 39.
“No new cases were recorded in Cameroon, Congo, Kenya, Rwanda, Uganda, South Africa, Côte d’Ivoire, or Liberia. The total number of recorded deaths stands at 541,” he said.
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A new global health emergency: All you need to know about mpox outbreak
According to The Ghana Times, the World Health Organization declared Wednesday that the increasing spread of mpox in Africa is a global health emergency, warning the virus might ultimately spill across international borders.
The announcement by WHO director-general Tedros Adhanom Ghebreyesus came after a meeting of the U.N. health agency’s emergency committee. The Africa Centers for Disease Control and Prevention declared mpox a public health emergency on the continent on Tuesday.
WHO said there have been more than 14,000 cases and 524 deaths in Africa this year, which already exceed last year’s figures.
So far, more than 96% of all cases and deaths are in a single country — Congo. Scientists are concerned by the spread of a new version of the disease there that might be more easily transmitted among people.
Here’s a look at what we know about mpox, and what might be done to contain it:
What is mpox?
Mpox, also known as monkeypox, was first identified by scientists in 1958 when there were outbreaks of a “pox-like” disease in monkeys. Until recently, most human cases were seen in people in central and West Africa who had close contact with infected animals.
In 2022, the virus was confirmed to spread via sex for the first time and triggered outbreaks in more than 70 countries across the world that had not previously reported mpox.
Mpox belongs to the same family of viruses as smallpox but causes milder symptoms like fever, chills and body aches. People with more serious cases can develop lesions on the face, hands, chest and genitals.
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What’s happening in Africa that’s causing all this concern?
The number of cases has jumped dramatically. Last week, the Africa CDC reported that mpox has now been detected in at least 13 African countries. Compared with the same period last year, the agency said cases are up 160% and deaths have increased by 19%.
Earlier this year, scientists reported the emergence of a new form of mpox in a Congolese mining town that can kill up to 10% of people and may spread more easily.
Unlike in previous mpox outbreaks, where lesions were mostly seen on the chest, hands and feet, the new form of mpox causes milder symptoms and lesions on the genitals. That makes it harder to spot, meaning people might also sicken others without knowing they’re infected.
WHO said mpox was recently identified for the first time in four East African countries: Burundi, Kenya, Rwanda and Uganda. All of those outbreaks were linked to the epidemic in Congo. Tedros said there was concern for the further spread of the disease within Africa and beyond.
In the Ivory Coast and South Africa, health authorities have reported outbreaks of a different and less dangerous version of mpox that spread worldwide in 2022.
What does an emergency declaration mean?
WHO’s emergency declaration is meant to spur donor agencies and countries into action. But the global response to previous declarations has been mixed.
Africa CDC Director General Dr. Jean Kaseya said the agency’s declaration of a public health emergency was meant “to mobilize our institutions, our collective will and our resources to act swiftly and decisively.” He appealed to Africa’s international partners for help, saying that the escalating caseload in Africa had largely been ignored.
“It’s clear that current control strategies aren’t working and there is a clear need for more resources,” said Michael Marks, a professor of medicine at the London School of Hygiene and Tropical Medicine. “If a (global emergency declaration) is the mechanism to unlock these things, then it is warranted,” he said.
What’s different about the current outbreak in Africa compared to the 2022 epidemic?
During the global outbreak of mpox in 2022, gay and bisexual men made up the vast majority of cases and the virus was mostly spread through close contact, including sex.
Although some similar patterns have been seen in Africa, children under 15 now account for more than 70% of the mpox cases and 85% of deaths in Congo.
Ahead of its emergency meeting, Tedros said officials were dealing with several mpox outbreaks in various countries with “different modes of transmission and different levels of risk.”
“Stopping these outbreaks will require a tailored and comprehensive response,” he said.
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Greg Ramm, Save the Children’s Congo director, said the organization was particularly worried about the spread of mpox in the crowded camps for refugees in the east, noting there were 345,000 children “crammed into tents in unsanitary conditions.” He said the country’s health system was already “collapsing” under the strain of malnutrition, measles and cholera.
Dr. Boghuma Titanji, an infectious diseases expert at Emory University, said it was unclear why children were so disproportionately hit by mpox in Congo. She said it might be because kids are more susceptible to the virus or that social factors, like overcrowding and exposure to parents who caught the disease, might explain it.
How might mpox be stopped?
The 2022 outbreak of mpox in dozens of countries was largely shut down with the use of vaccines and treatments in rich countries, in addition to convincing people to avoid risky behaviour. But barely any vaccines or treatments have been available in Africa.
Marks, of the London School of Hygiene and Tropical Medicine, said that immunization would likely help — including inoculating people against smallpox, a related virus.
“We need a large supply of vaccine so that we can vaccinate populations most at risk,” he said, adding that would mean sex workers, children and adults living in outbreak regions.
Congo has said it’s in talks with donors about possible vaccine donations and has gotten some financial aid from Britain and the U.S.
WHO had already released $1.45 million from its emergency fund to support the response to mpox in Africa, but said it needs an initial $15 million to fund that response.
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