A confirmed H1N1 outbreak has hit Anum Senior High School in the Eastern Region.
Nine samples from the school tested positive for the respiratory disease, also known as Swine Flu.
The Noguchi Memorial Institute for Medical Research confirmed the cases.
Meanwhile, suspected cases have emerged at Bosu Secondary Technical School, where additional samples have been taken for testing.
Results are still pending.
Health authorities are closely monitoring the situation and have urged the public to remain vigilant.